- Tyler Perry Character (Dr. Alex Cross)
- Rachel Nichols Character (Monica Ashe)
- Jean Reno Character (Leon Mercier)
- Matthew Fox Character (Picasso)
- Giancarlo Esposito Character (Daramus Holiday)
- Edward Burns Character (Tommy Kane)
- Cicely Tyson Character (Nana Mama)
- John C. McGinley Character (Richard Brookwell)
- Chad Lindberg Character (Vincent Dardis)
- Carmen Ejogo Character (Maria Cross)
- Stephanie Jacobsen Character (Fan Yau)
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